Michael Bartlett, Ph.D.
Pharmaceutical and Biomedical Sciences
|B.S. Chemistry||North Carolina State Univ.||Raleigh||1990|
|Ph.D. Analytical Chemistry||Georgia Institute of Technology||Atlanta||1994|
- Post-doctoral Experience
- Postdoctoral Research Associate, Department of Medicinal Chemistry, University of Utah, 1994-1995
- Honors and Awards
- G.E. Philbrook Award for Undergraduate Teaching, Northeast Georgia Chapter of the American Chemical Society, 2005
Named College of Pharmacy Teacher of the Year, 2002
Named Phi Delta Chi, College of Pharmacy Teacher of the Year, 2001
Named Phi Delta Chi, College of Pharmacy Teacher of the Year, 2000
American Association of Colleges of Pharmacy New Investigator Award, 2000
American Society for Mass Spectrometry Young Investigator Award, 1999
Outstanding Dissertation Award, Georgia Institute of Technology, 1994
Award from International Society for the Study of Xenobiotics for Significant Contribution to the Field of Xenobiotics, 1990
- Research Interests
- The Bartlett Laboratory focuses on the development and validation of novel analytical methodologies to address important biomedical issues related to the adsorption, distribution, metabolism and elimination of therapeutic agents. The laboratory is currently investigating two important areas. 1) Understanding the mechanisms underlying the transport and distribution of therapeutic agents across membrane barriers such as the placenta and the blood brain barrier. 2) Quantitation of macromolecules. The increased use of biotechnology-based therapies has created a demand for quantitative methods to assay these agents from biological samples. Our work focuses on using mass spectrometry in conjunction with liquid chromatography and capillary electrophoresis to isolate and measure therapeutic proteins and oligonucleotides with high precision and accuracy.
- Representative Publications
- G. Zhang, A.V. Terry and M.G. Bartlett, “Liquid Chromatography / Tandem Mass Spectrometry for the Simultaneous Determination of Olanzipine, Risperidone, 9-Hydroxyrisperidone, Clozapine, Haloperidol and Ziprasidone in Rat Plasma.” Rapid Communications in Mass Spectrometry, 21, 920-928 (2007).
L.N. Williamson and M.G. Bartlett, “Quantitative Liquid Chromatography-Time of Flight Mass Spectrometry.” Biomedical Chromatography, 21, 567-576 (2007).
Y. Liu, S. Muralidhara, J.V. Bruckner and M.G. Bartlett, “Trace Level Determination of Trichloroethylene from Biological Samples by Headspace Solid Phase Microextraction Gas Chromatography Negative Chemical Ionization Mass Spectrometry.” Rapid Communications in Mass Spectrometry, 22, 797-806 (2008).
M. Xu, A.V. Terry and M.G. Bartlett, “Determination of Diisopropylfluorophosphate (DFP) in Rat Plasma and Brain Tissue by Headspace Solid-Phase Microextraction Gas Chromatography Mass Spectrometry.” Rapid Communications in Mass Spectrometry, 22, 3069-3075 (2008).
A.V. Terry, S.E. Warner, L. Vandenhuerk, A. Pillai, S.P. Mahadik, G. Zhang and M.G. Bartlett, “Negative Effects of Chronic Oral Chlorpromazine and Olanzapine Treatment on the Performance of Tasks Designed to Assess Spatial Learning and Working Memory in Rats.” Neuroscience, 156, 1005-1016 (2008).