Michael Bartlett, Ph.D.
Georgia Athletic Association Professor
Pharmaceutical and Biomedical Sciences
|Ph.D. Analytical Chemistry||Georgia Institute of Technology||Atlanta||1994|
|B.S. Chemistry||North Carolina State Univ.||Raleigh||1990|
- Post-doctoral Experience
- Postdoctoral Research Associate, Department of Medicinal Chemistry, University of Utah, 1994-1995
- Honors and Awards
- 2013 Outstanding Manuscript in Analysis and Pharmaceutical Quality from the American Association for Pharmaceutical Scientists
2011 Elected Fellow of the American Association for Pharmaceutical Scientists
2010 Research Achievement Award in Analysis and Pharmaceutical Quality from the American Association for Pharmaceutical Scientists
2007 Certificate of Appreciation, Alfred P. Sloan Foundation, Advancing Underrepresented Minority Students in STEM disciplines
G.E. Philbrook Award for Undergraduate Teaching, Northeast Georgia Chapter of the American Chemical Society, 2005
Named College of Pharmacy Teacher of the Year, 2002
Named Phi Delta Chi, College of Pharmacy Teacher of the Year, 2001
Named Phi Delta Chi, College of Pharmacy Teacher of the Year, 2000
American Association of Colleges of Pharmacy New Investigator Award, 2000
- Research Interests
- The Bartlett Laboratory focuses on the development and validation of novel analytical methodologies to address important biomedical issues related to the adsorption, distribution, metabolism and elimination of therapeutic agents. The laboratory is currently investigating two important areas. 1) Understanding the mechanisms underlying the transport and distribution of therapeutic agents across membrane barriers such as the placenta and the blood brain barrier. 2) Quantitation of macromolecules. The increased use of biotechnology-based therapies has created a demand for quantitative methods to assay these agents from biological samples. Our work focuses on using mass spectrometry in conjunction with liquid chromatography and capillary electrophoresis to isolate and measure therapeutic proteins and oligonucleotides with high precision and accuracy.
- Representative Publications
- B. Chen and M.G. Bartlett, “Evaluation of mobile phase composition for enhancing sensitivity of targeted quantification of oligonucleotides using ultra-high performance liquid chromatography and mass spectrometry (UHPLC-MS/MS): Application to phosphorothioate DNA.” Journal of Chromatography A, 1288, 73-81 (2013).
P. Li, B.J. Albrecht, X. Yan, M. Gao, H.R. Weng and M.G. Bartlett, “A rapid analytical method for the quantification of paclitaxel in rat plasma and brain tissue using high performance liquid chromatography tandem mass spectrometry.” Rapid Communications in Mass Spectrometry, 27, 2127-2134 (2013).
A.C. McGinnis, B.S. Cummings and M.G. Bartlett, “Ion exchange liquid chromatography method for the direct determination of small ribonucleic acids.” Analytica Chimica Acta, 799, 57-67 (2013).
A.C. McGinnis, E.C Grubb and M.G. Bartlett, “Systematic optimization of ion-pairing agents and hexafluoroisoproponal for enhanced electrospray ionization mass spectrometry of oligonucleotides.” Rapid Communications in Mass Spectrometry, 27, 2655-2664 (2013).
D. Gullick, A. Popovici, H.C. Young, J.V. Bruckner, B.S. Cummings, P. Li and M.G. Bartlett, “Determination of deltamethrin in rat plasma and brain tissue using gas chromatography-negative chemical ionization mass spectrometry.” Journal of Chromatography B, 960, 158-165 (2014).