Harry A. Dailey, Ph.D.
Biomedical and Health Sciences Institute
|B.A. Bacteriology||University of California||Los Angeles||1972|
|Ph.D. Microbiology||University of California||Los Angeles||1976|
- Post-doctoral Experience
- Postdoctoral Assistant, University of Connecticut Health Center, 1976-1980
- Honors and Awards
- University of Georgia, CURO Excellence in Undergraduate Research Mentoring Award, 2008
Fellow of American Association for the Advancement of Science, 2009
Fellow of American Academy of Microbiology, 2010
Chair, 2012 Gordon Research Conference, Chemistry and Biology of Tetrapyrroles
- Research Interests
- Research focuses mainly on the terminal steps of heme biosynthesis. Projects have ranged from structure-function studies on the terminal two enzymes, protoporphyrinogen oxidase (PPO) and ferrochelatase, characterization of pathway regulation during erythroid cell differentiation, to creation of a mouse model for variegate porphyria, a genetic disease in man resulting from a deficiency in PPO. With regard to drug discovery, it is of note that a significant number of drugs are metabolized by cytochrome P450s and coordinate heme synthesis is required for cytochrome biosynthesis and heme is the essential cofactor for these enzymes. Additionally, individuals suffering from any of the seven porphyrias are very sensitive to and are negatively impacted by a wide variety of drugs.
- Representative Publications
- Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock A, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar J, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C, Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA*, Kaplan J*, Paw BH*. Mitochondrial Atpif1 regulates heme synthesis in developing erythroblasts. 2012, Nature 491: 608-612. [*co-corresponding senior authors].
Wu, B, Novelli, J, Jiang, D, Dailey, HA, Landmann, F, Ford, L, Taylor, MJ, Carlow, CKS, Foster, JM, and Slatko, BE, 2013. Interdomain lateral gene transfer of an essential ferrochelatase gene in human parasitic nematodes, Proc Natl Acad Sci USA 110:7748-7753.
Dailey, H.A. and Meissner, P.N. 2013. In: Hemoglobin and its Disorders (Schechter, A.N. Weatherall, D., and Nathan, N., eds), Cold Spring Harb Perspect Med, doi:10.1101/cshperspect.a011676 (on line), 1-14.
Yien YY, Robledo RF, Schultz IJ, Takahashi-Makise N, Gwynn B, Bauer DE, Dass A, Yi G, Li L, Hildick-Smith GJ, Cooney JD, Pierce EL, Mohler K, Dailey TA, Miyata N, Kingsley PD, Garone C, Hattangadi SM, Huang H, Chen W, Keenan EM, Shah DI, Schlaeger TM, DiMauro S, Orkin SH, Cantor AB, Palis J, Koehler CM, Lodish HF, Kaplan J, Ward DM, Dailey HA, Phillips JD, Peters LL, Paw BH, 2014. TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest. pii: 76979. doi: 10.1172/JCI76979. [Epub ahead of print]
Dailey, HA, Gerdes, S, Dailey, TA, Burch, JS, and Phillips, JD, 2015. Noncanonical coproporphyrin-dependent bacterial heme biosynthesis pathway that does not use protoporphyrin. Proc Natl Acad Sci USA 112: 2210-2215.doi/10.1073/pnas.1416285112.