Faculty: Biography
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Harry A. Dailey, Ph.D. Professor Biomedical and Health Sciences Institute
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| Biosketch | |||
|---|---|---|---|
| B.A. Bacteriology | University of California | Los Angeles | 1972 |
| Ph.D. Microbiology | University of California | Los Angeles | 1976 |
- Post-doctoral Experience
- Postdoctoral Assistant, University of Connecticut Health Center, 1976-1980
- Honors and Awards
- 2000, Merrin Scholar, University of Cape Town
1982-1987, Research Career Development Award, NIDDK, University of Georgia
1972, University of California Presidents Undergraduate Fellowship, University of California, UCLA
1972, American Heart Association Postdoctoral Fellowship, American Heart Association, University of Connecticut Health Center
1971, Summer Undergraduate Research Program, NSF, UCLA
- Research Interests
- Research focuses mainly on the terminal steps of heme biosynthesis. Projects have ranged from structure-function studies on the terminal two enzymes, protoporphyrinogen oxidase (PPO) and ferrochelatase, characterization of pathway regulation during erythroid cell differentiation, to creation of a mouse model for variegate porphyria, a genetic disease in man resulting from a deficiency in PPO. With regard to drug discovery, it is of note that a significant number of drugs are metabolized by cytochrome P450s and coordinate heme synthesis is required for cytochrome biosynthesis and heme is the essential cofactor for these enzymes. Additionally, individuals suffering from any of the seven porphyrias are very sensitive to and are negatively impacted by a wide variety of drugs.
- Representative Publications
- Shepherd, M., Dailey, T.A., and Dailey, H.A. 2006 A new class of [2Fe-2S] clusters in microbial protoporphyrin ferrochelatases . Biochem J . 397: 47-52.
Medlock, A.E., and Dailey, H.A. 2006. Control and regulation of mammalian heme synthesis. In Tetrapyrroles (Martin, M. and Smith, A., eds) Landes Bioscience (UK)
Medlock, A., Swartz, L., Dailey, T.A., Dailey, H.A., and Lanzilotta, W.N. 2007. Substrate interactions with human ferrochelatase. Proc Natl Acad Sci, USA 104: 1789-1793.
Dailey, H.A. and Lanzilotta, W.N., 2007. Human Ferrochelatase. In Handbook of Metalloproteins, (Messerschmidt, A., ed) John Wiley & Sons, Ltd., (UK)