Faculty: Biography

Harry A. Dailey, Ph.D.
Professor
Biomedical and Health Sciences Institute
Address: Paul D. Coverdell Center
University of Georgia
Athens, GA 30602
Office: N226
Phone: (706) 542-2690
Email: hdailey@uga.edu
Biosketch
Ph.D. MicrobiologyUniversity of CaliforniaLos Angeles1976
B.A. BacteriologyUniversity of CaliforniaLos Angeles1972
Post-doctoral Experience
Postdoctoral Assistant, University of Connecticut Health Center, 1976-1980
Honors and Awards
2010, Fellow of the American Academy of Microbiology
2000, Merrin Scholar, University of Cape Town
1982-1987, Research Career Development Award, NIDDK, University of Georgia
1972, University of California Presidents Undergraduate Fellowship, University of California, UCLA
1972, American Heart Association Postdoctoral Fellowship, American Heart Association, University of Connecticut Health Center
1971, Summer Undergraduate Research Program, NSF, UCLA
Research Interests
Research focuses mainly on the terminal steps of heme biosynthesis. Projects have ranged from structure-function studies on the terminal two enzymes, protoporphyrinogen oxidase (PPO) and ferrochelatase, characterization of pathway regulation during erythroid cell differentiation, to creation of a mouse model for variegate porphyria, a genetic disease in man resulting from a deficiency in PPO. With regard to drug discovery, it is of note that a significant number of drugs are metabolized by cytochrome P450s and coordinate heme synthesis is required for cytochrome biosynthesis and heme is the essential cofactor for these enzymes. Additionally, individuals suffering from any of the seven porphyrias are very sensitive to and are negatively impacted by a wide variety of drugs.
Representative Publications
Shepherd, M., Dailey, T.A., and Dailey, H.A. 2006 A new class of [2Fe-2S] clusters in microbial protoporphyrin ferrochelatases . Biochem J . 397: 47-52.

Medlock, A.E., and Dailey, H.A. 2006. Control and regulation of mammalian heme synthesis. In Tetrapyrroles (Martin, M. and Smith, A., eds) Landes Bioscience (UK)

Medlock, A., Swartz, L., Dailey, T.A., Dailey, H.A., and Lanzilotta, W.N. 2007. Substrate interactions with human ferrochelatase. Proc Natl Acad Sci, USA 104: 1789-1793.

Dailey, H.A. and Lanzilotta, W.N., 2007. Human Ferrochelatase. In Handbook of Metalloproteins, (Messerschmidt, A., ed) John Wiley & Sons, Ltd., (UK)
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