Stephen Dalton, Ph.D.
Professor, GRA Chair
Biochemistry and Molecular Biology
|B.S.||Flinders University||South Australia||1983|
|Ph.D.||University of Adelaide||Adelaide, Australia||1988|
- Post-doctoral Experience
- Postdoc, Institute of Molecular Pathology, Vienna, Austria, 1988-1989
Postdoc, Imperial Cancer Research Fund, London, UK, 1989-1992
- Honors and Awards
- Georgia Research Alliance Eminent Scholar in Molecular Cell Biology
Georgia Cancer Coalition Distinguished Cancer Scientist
- Research Interests
- Core interests are in the basic biology of murine and human embryonic stem cells and how this understanding can be used to develop cell based therapies to cure degenerative diseases and for the repair of damaged tissue. Research in the murine ES cell (mESC) area includes:
• understanding how ESCs retain their ability to proliferate indefinitely while retaining their unlimited differentiation potential
• using ES cells as a model to understand aspects of cancer
• the study of cell cycle regulation and differentiation
• characterization of glycoprotein, glycolipid epitopes on the cell surface and how this relates to ESC biology
• understanding the biology of pluripotent cells in the preimplantation-early postimplantation stages of development
• nuclear structure and chromosome dynamics in stem cells
Interests in human ES cells (hESCs) are focused on:
• understanding cell cycle control and self-renewal
• understanding the basic mechanisms by which pluripotent cells make fate decisions in vitro and as part of human development
• the development of strategies that will allow us to differentiate hESCs into pancreatic b-cells as part of a therapy for diabetes
- Representative Publications
- Stead, E., White., Faast, R., Conn, S., Goldstone, S., Rathjen, J., Dhingra, U., Rathjen, P., Walker, D. and Dalton, S. (2002) Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene, 21, 8320-8333.
Reynolds, D., Shi, B.J., McLean, C., Katsis, F., Kemp, B. and Dalton, S.. (2003) Recruitment of Thr319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Genes Dev. 17, 1789-1802.
Faast, R., White, J., Crocker, L., Cartwright, P., Sarcevic, B. and Dalton, S. (2004) Cdk6-cyclin D3 Activity in Murine ES cells is Resistant to Inhibition by p16INK4a. Oncogene, 23, 491-502.
Cartwright, P., Mclean, C., Sheppard, A., Rivett, D., Jones, K. and Dalton, S. (2005). LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development, 132, 885-896.
White, J., Stead, E., Faast, R., Conn, S., Cartwright, P. and Dalton, S. (2005). Developmental activation of the Rb-E2F pathway and establishment of cell cycle regulated Cdk activity during embryonic stem cell differentiation. Mol. Biol. Cell 16, 2018-2027.