Faculty: Biography

Stephen Dalton, Ph.D.
Professor
Biochemistry and Molecular Biology
Address: Paul D. Coverdell Center
University of Georgia
Athens, GA 30602
Office: N245
Phone: (706) 583-0480
Email: sdalton@uga.edu
Biosketch
Ph.D.University of AdelaideAdelaide, Australia1988
B.S.Flinders UniversitySouth Australia1983
Post-doctoral Experience
Postdoc, Institute of Molecular Pathology, Vienna, Austria, 1988-1989
Postdoc, Imperial Cancer Research Fund, London, UK, 1989-1992
Honors and Awards
Georgia Research Alliance Eminent Scholar in Molecular Cell Biology
Georgia Cancer Coalition Distinguished Cancer Scientist
Research Interests
Core interests are in the basic biology of murine and human embryonic stem cells and how this understanding can be used to develop cell based therapies to cure degenerative diseases and for the repair of damaged tissue. Research in the murine ES cell (mESC) area includes:
understanding how ESCs retain their ability to proliferate indefinitely while retaining their unlimited differentiation potential
using ES cells as a model to understand aspects of cancer
the study of cell cycle regulation and differentiation
characterization of glycoprotein, glycolipid epitopes on the cell surface and how this relates to ESC biology
understanding the biology of pluripotent cells in the preimplantation-early postimplantation stages of development
nuclear structure and chromosome dynamics in stem cells

Interests in human ES cells (hESCs) are focused on:
understanding cell cycle control and self-renewal
understanding the basic mechanisms by which pluripotent cells make fate decisions in vitro and as part of human development
the development of strategies that will allow us to differentiate hESCs into pancreatic b-cells as part of a therapy for diabetes
Representative Publications
Stead, E., White., Faast, R., Conn, S., Goldstone, S., Rathjen, J., Dhingra, U., Rathjen, P., Walker, D. and Dalton, S. (2002) Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene, 21, 8320-8333.

Reynolds, D., Shi, B.J., McLean, C., Katsis, F., Kemp, B. and Dalton, S.. (2003) Recruitment of Thr319-phosphorylated Ndd1p to the FHA domain of Fkh2p requires Clb kinase activity: a mechanism for CLB cluster gene activation. Genes Dev. 17, 1789-1802.

Faast, R., White, J., Crocker, L., Cartwright, P., Sarcevic, B. and Dalton, S. (2004) Cdk6-cyclin D3 Activity in Murine ES cells is Resistant to Inhibition by p16INK4a. Oncogene, 23, 491-502.

Cartwright, P., Mclean, C., Sheppard, A., Rivett, D., Jones, K. and Dalton, S. (2005). LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism. Development, 132, 885-896.

White, J., Stead, E., Faast, R., Conn, S., Cartwright, P. and Dalton, S. (2005). Developmental activation of the Rb-E2F pathway and establishment of cell cycle regulated Cdk activity during embryonic stem cell differentiation. Mol. Biol. Cell 16, 2018-2027.
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