Roberto Docampo, Ph.D.
|Ph.D.||Federal University of Rio de Janeiro||Brazil||1977|
|Ph.D.||University of Buenos Aires||Argentina||1979|
|M.D.||University of Buenos Aires||Argentina||1972|
- Post-doctoral Experience
- National Institute of Environmental Health Sciences, National Institutes of Health, 1982-1986
- Honors and Awards
- Doctor Honoris Causa, National University of San Martin, Buenos Aires, Argentina (2013)
Roots Award, Minister of Science, Technology, and Innovation, Argentina (2013)
Elected Fellow of the American Association for the Advancement of Science (December 2010)
Elected Fellow of the American Academy of Microbiology, March 2010
Georgia Research Alliance and Barbara and Sanford Orkin Eminent Scholar in Tropical and Emerging Global Diseases and Cellular Biology
Member of the Editorial Board of Molecular and Biochemical Parasitology (1983-present), Experimental Parasitology (2005-2009), The Biochemical Journal (2005-2009) and Antimicrobial Agents and Chemotherapy (2008-2012); Associate Editor of The Journal of Eukaryotic Microbiology (2004-2007); Guest Editor of Acta Tropica (2002-2005), and Microscopy and Microanalysis (2004)
Foreign Member, Brazilian Academy of Sciences (1999-present)
Burroughs Wellcome Fund New Initiatives in Malaria Research Award (1999-2001) and Burroughs Wellcome Fund/American Society for Microbiology Visiting Professor in the Microbiological Sciences (2000-2001)
- Research Interests
- Major research interests involve the rational approach to chemotherapeutic control of parasitic infections. The main, basic strategy is to search for metabolic pathways in parasites that may be essential for survival of the parasites but may not find an equivalent counterpart in the host. Thus, one could look for specific inhibitors of such metabolic activities as possible means of controlling the parasites without damaging the hosts. Currently our efforts are concentrated on the characterization of ion homeostasis mechanisms in trypanosomatids and malaria parasites, and in the mechanisms involved in invasion of host cells by intracellular parasites.
- Representative Publications
- Huang, G., Vercesi, A.E., and Docampo, R. (2013) Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter. Nat. Commun. 4, 2865.
Lander, N., Ulrich, P.N., and Docampo, R. (2013) Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection. J. Biol. Chem. 288, 34205-34216.
Galizzi, M., Bustamante, J., Fang, J., Miranda, K., Soares Medeiros, L., Tarleton R., and Docampo, R. (2013) Evidence for a role of vacuolar soluble pyrophosphatase and inorganic polyphosphate in Trypanosoma cruzi persistence. Mol. Microbiol. 90, 699-715.
Huang, G., Bartlett, P.J., Thomas, A.P., Moreno, S.N.J., and Docampo, R. (2013) Acidocalcisomes of Trypanosoma brucei have an inositol 1,4,5-trisphosphate receptor that is required for growth and infectivity. Proc. Natl. Acad. Sci. USA 110, 1887-1892.
Jimenez, V., and Docampo, R. (2012) Molecular and electrophysiological characterization of a novel cation channel of Trypanosoma cruzi. PLoS Path. 8 (6) e1002750.