Roberto Docampo, Ph.D.
|Ph.D.||Federal University of Rio de Janeiro||Brazil||1977|
|Ph.D.||University of Buenos Aires||Argentina||1979|
|M.D.||University of Buenos Aires||Argentina||1972|
- Post-doctoral Experience
- National Institute of Environmental Health Sciences, National Institutes of Health, 1982-1986
- Honors and Awards
- Doctor Honoris Causa, National University of San Martin, Buenos Aires, Argentina (2013)
Roots Award, Minister of Science, Technology, and Innovation, Argentina (2013)
Elected Fellow of the American Association for the Advancement of Science (December 2010)
Elected Fellow of the American Academy of Microbiology, March 2010
Georgia Research Alliance and Barbara and Sanford Orkin Eminent Scholar in Tropical and Emerging Global Diseases and Cellular Biology
Member of the Editorial Board of Molecular and Biochemical Parasitology (1983-present), Experimental Parasitology (2005-present), The Biochemical Journal (2005-2014), Antimicrobial Agents and Chemotherapy (2008-present) and ACS Infectious Diseases (2015-present); Associate Editor of The Journal of Eukaryotic Microbiology (2004-2007); Guest Editor of Acta Tropica (2002-2005), and Microscopy and Microanalysis (2004); Editor-in-Chief of the Journal of Eukaryotic Microbiology (2012-present).
Foreign Member, Brazilian Academy of Sciences (1999-present)
Burroughs Wellcome Fund New Initiatives in Malaria Research Award (1999-2001) and Burroughs Wellcome Fund/American Society for Microbiology Visiting Professor in the Microbiological Sciences (2000-2001)
- Research Interests
- Major research interests involve the rational approach to chemotherapeutic control of parasitic infections. The main, basic strategy is to search for metabolic pathways in parasites that may be essential for survival of the parasites but may not find an equivalent counterpart in the host. Thus, one could look for specific inhibitors of such metabolic activities as possible means of controlling the parasites without damaging the hosts. Currently our efforts are concentrated on the characterization of ion homeostasis mechanisms in trypanosomatid parasites, and in the mechanisms involved in invasion of host cells by intracellular parasites.
- Representative Publications
- Veiga-Santos, P., Li, K., Huang, G., Lameira, L., Ulisses de Carvalho, T.M., Galizzi, M., Shang, N., Li, Q., Gonzalez-Pacanowska, D., Hernandez-Rodriguez, V., Benaim, G., Guo, R.T., Urbina, J., Docampo, R., de Souza, W., and Oldfield, E. (2015) SQ109: A New Drug Lead for Chagas Disease. Antimicrob. Agents Chemother 59, 1950-1961.
Huang, G., Ulrich, P.N., Storey, M., Johnson, D., Tischer, J., Tovar, J.A., Moreno, S.N., Orlando, R. and Docampo, R. (2014) Proteomic analysis of the acidocalcisome, an organelle conserved from bacteria to human cells. PLoS Path. 10 (12): e1004555.
Niyogi, S., Mucci, J., Campetella, O., and Docampo, R. (2014) Rab11 regulates trafficking of trans-sialidase to the plasma membrane through the contractile vacuole complex of Trypanosoma cruzi. PLoS Pathog. 10 (6): e1004224.
Huang, G., Vercesi, A.E., and Docampo, R. (2013) Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter. Nat. Commun. 4, 2865.
Lander, N., Ulrich, P.N., and Docampo, R. (2013) Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection. J. Biol. Chem. 288, 34205-34216.