Svein Oie, Ph.D.
Dean, College of Pharmacy and Professor
Pharmaceutical and Biomedical Sciences
|Cand. Pharm||University of Oslo||Oslo, Norway||1966|
|Ph.D.||State University of New York||Buffalo, NY||1975|
- Post-doctoral Experience
- Postdoctoral Fellow Pharmaceutics, State University of New York School of Pharmacy, Buffalo NY, 1975
- Honors and Awards
- Fellowship, Norwegian Institute for Natural Sciences, 1971-73
Long Award for Excellence in Teaching, School of Pharmacy, UCSF, 1983
University of Helsinki Medal, University of Helsinki, Finland, 1992
Third Annual Per Finholt Lecture, University of Oslo, Norway, 1992
- Research Interests
- A number of pharmacologically active proteins and peptides have recently been identified for use as potential drugs. Two factors in particular handicap these compounds from being clinically active: 1) poor absorption across membranes and 2) instability when administered per os. Clearly, the ability to increase the transfer of these compounds across various membranes, particularly the gastrointestinal wall, would make a significant contribution to optimizing this form of drug therapy and our research interest is focused on exploring various transport mechanisms to develop a means to transport these poorly absorbed compounds per os.
Selectively targeting specific cell types, as a novel drug delivery approach, requires identification of the unique characteristics of the designated target cells. Mechanisms for developing delivery systems that will associate with for individual cell types followed by cellular uptake of the delivery system containing the drug or local release of the associated drugs are being explored.
A number of factors are known to affect the disposition and pharmacologic activity of drugs. These include disease state, genetic and environmental factors, anthropomorphic and physiologic conditions, proteins and protein binding. Current interest focuses on effect of the activation of the acute phase response in disease and trauma on drug disposition.
- Representative Publications
- Clinical pharmacology of moclobemide during chronic administration of high doses to healthy subjects. J. Dingemanse, N. Wood, T. Guentert, S. Řie, M. Ouwerkerk, and R. Amrein, Psychopharmacology, 140:164-172, 1998
VLDL-resembling phospholipid-submicron emulsion for cholesterol-based drug targeting. M. Shawer, P. Greenspan, S. Řie, and D.R. Lu, J Pharm Sci, 91:1405-1413, 2002
Sequential first-pass metabolism of nortilidine: The active metabolite of the synthetic opioid drug tilidine. J.P. Hajda, E. Jähnchen, S. Řie, and D. Trenk, J Clin Pharmacol 42: 1-5, 2002
Synthesis, preformulation and liposomal formulation of cholesteryl carborene esters with various fatty chains. F. Alanazi, H. Li, D.S. Halpern, S. Řie, and D.R. Lu, International J. Pharmaceutics, 255: 189-197, 2003
In vitro gene transfection to glioma cells using a novel and less cytotoxic artificial lipoprotein delivery system. G. Pan, M. Shawer, S. Řie, and D.R. Lu, Pharm. Research, 20: 738-744, 2003