Faculty: Biography

Binghe Wang, Ph.D.
Professor
Chemistry
Address: P.O. Box 3965
Georgia State University
Atlanta, GA 30302-3965
Office:
Phone: (404) 413-5544
Email: wang@gsu.edu
Biosketch
B.S. Medicinal ChemistryBeijing Medical UniversityBeijing, China1982
Ph.D. Medicinal ChemistryUniversity of KansasLawrence, KS1991
Post-doctoral Experience
Post-doctoral Research Associate, Department of Pharmaceutical Chemistry, University of Kansas School of Pharmacy, 1992-1993
Post-doctoral Research Associate, Department of Chemistry, University of Arizona, 1992
Honors and Awards
Georgia Research Alliance Eminent Scholar in Drug Discovery
Georgia Cancer Coalition Distinguished Cancer Scientist
Research Interests
Research interests are in the general areas of drug design, drug delivery, bioorganic chemistry, combinatorial chemistry, molecular recognition and fluorescent sensor design. Specifically, we are working on (1) the development of a new type of therapeutics targeted on drug-resistant cancer, (2) new cancer diagnostics by recognizing the difference in glycosylation patterns of pathologically relevant glycoproteins, (3) new MRI contrast agents based on cancer biomarkers, (4) phosphodiesterase inhibitors, and (5) new antimicrobial agents.
Representative Publications
Zou, W.; He, M; Yue, P.; Zhou, Z.; Lin, N.; Lonial, S.; Khuri, F.R.; Wang, B.; Sun, S-Y. “Vitamin C Inactivates the Proteasome Inhibitor PS-341 (Bortezomib) in Human Cancer Cells” Clin. Cancer Res. 2006, 12, 273-280 (Editorial Clin. Cancer Res. 2006, 12, 3-4).

Yan, J.; Jin S.; Wang, B. “A Novel Redox-Sensitive Protecting Group for Boronic Acids, MPMP-Diol” Tetrahedron Lett. 2005, 46, 8503-8505.

Yang, W.; Fan, H.; Gao, S.; Gao, X.; Ni, W.; Karnati, V.; Hooks, W.B.; Carson, J.; Weston, B.; Wang, B. “The First Fluorescent Diboronic Acid Sensor Specific for Hepatocellular Carcinoma Cells Expressing Sialyl Lewis X” Chem. Biol. 2004, 11, 439-448.

Zych, L.; Yang, W.; Griffin, K.; Liao, Y.; Wang, B. “Coumarin-based Cyclic Prodrugs of Peptides-The Effect of Substitution” Bioorg. Chem. 2004, 32, 109-123.
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