Catherine A. White, Ph.D.
Pharmaceutical and Biomedical Sciences
|Ph.D. Pharmaceutical Sciences||University of Washington||Seattle, WA||1986|
|B.S. Pharmacy||St. Louis College of Pharmacy||St. Louis, MO||1980|
- Post-doctoral Experience
- Postdoctoral Fellowship, University of Kansas Medical Center, Kansas City, KS, 1987
- Honors and Awards
- Member, Board of Directors, International Society of Medical Chronobiology
Director, Educational and Training Programs for CLEARMADD
- Research Interests
- Gender may influence the pharmacokinetics and efficacy/toxicity of drugs and herbal products. Women experience a higher incidence of adverse drug reactions and the cause of this is unknown. The pharmacokinetics of the drugs may be influenced by gender or the pharmacodynamics may be altered. This research group is examining the influence of gender on the clearance mechanisms of various drugs and on the pharmacokinetics and toxicity of various pesticides. The tissue uptake of liposomal encapsulated ampicillin increased 3 to 10-fold in females as compared to male rats.
One focus of the research program is the placental transport of antiviral agents and drugs of abuse. Maternal and fetal disposition of cocaine and several antiviral agents, which are used to treat HIV and HSV, have been examined. A recently published study examining the interaction of AZT and Acyclovir (ACV) indicated that uptake of antiviral agents into the fetal compartment (fetus and amniotic fluid) involves a carrier mediated process as well as passive diffusion. The following figure illustrates this point. When ACV is administered in conjunction with AZT, the fetal levels of ACV are significantly higher suggesting up-regulation of transporters in the placenta.
- Representative Publications
- Alnouti, S.D. Lewis, C.A. White and M.G. Bartlett*, “Determination of Zidovudine and Lamivudine in Maternal Plasma, Amniotic Fluid, Fetal and Placental Tissues by High Performance Liquid Chromatography Electrospray Tandem Mass Spectrometry.” Rapid Communications in Mass Spectrometry, 19, 503-508 (2005).
Y. Ding, L.N. Williamson, C.A. White, and M.G. Bartlett*, “Determination of 2’,3’-dideoxycytidine in maternal plasma, amniotic fluid, placental and fetal tissues by high-performance liquid chromatography.” Journal of Chromatography B, 811, 183-189 (2004).
S.D. Brown, M.G. Bartlett and C.A. White*, “Comparative Pharmacokinetics of Intravenous Acyclovir, Zidovudine and Acyclovir / Zidovudine Therapies in the Pregnant Rat." Antimicrobial Agents and Chemotherapy, 47 (3) 991-996, 2003
M.H. Lumpkin, J.V. Bruckner, J.L. Campbell, C.E. Dallas, C.A. White and J.W. Fisher, “Plasma Binding of Trichloroacetic acid in Mice, Rats and Humans under Cancer Bioassay and Environmental Levels, Drug Metabolism and Disposition, V31, No10, 1203-1207, 2003
K.M. Lee, S. Muralidhara, C.A. White, and J.V. Bruckner, Mechanisms of the Dose-Dependent Kinetics of Trichloroethylene: Oral Bolus Dosing of Rats, Toxicology and Applied Pharmacology, 164 (1) 55-64, April 1, 2000.