Timothy Long, Ph.D.
Pharmaceutical and Biomedical Sciences
|B.S. Biology||Univ. of South Florida||Tampa||1999|
|Ph.D. Chemistry||Univ. of South Florida||Tampa||2003|
- Post-doctoral Experience
- Research Associate, University of Notre Dame, Notre Dame, IN 2004-2006
- Honors and Awards
- Research Interests
- Research interests are in the development of new drugs to treat infections. Presently, the lab is studying antiparasitic agents for the treatment of tropical and neglected diseases including malaria and trypanosomiasis. The compounds under investigation are based on mitochondrion-acting drugs such as atovaquone. Through collaborations with other research groups, we are working to develop a new molecular design of antagonists that have been discovered to be efficacious growth inhibitors of Plasmodium and Trypanosoma spp.
- Representative Publications
- Mock, J. N; Taliaferro, J. P.; Lu, X.; Patel, S. K.; Cummings, B. S.; Long, T. E. "Haloenol Pyranones and Morpholinones as Antineoplastic Agents of Prostate Cancer," Bioorg. Med. Chem. Lett. (2012), 22, 4854-4858.
Long, T. E.; Lu, X.; Galizzi, M.; Docampo, R.; Gut, J.; Rosenthal, P. J. "Phosphonium Lipocations as Antiparasitic Agents," Bioorg. Med. Chem. Lett. (2012), 22, 2976-2979.
Lu, X; Long T. E "Asymmetric Synthesis of Monocyclic β-Lactams from L-Cysteine Using Photochemistry," Tetrahedron Lett. (2011), 52, 5051-5054.
Lu, X; Long, T.E. “o-Nitrophenyl Sulfoxides: Efficient Precursors for the Mild Preparation of Alkenes,” Journal of Organic Chemistry (2010), 75(1), 249-252.
Patel, S. K.; Long, T. E. “Preparation of vinylglycines by thermolysis of homocysteine sulfoxides,” Tetrahedron Letters (2009), 50(36), 5067-5070.