Fredrick Quinn, Ph.D.
Professor and Head
|M.A. Microbiology||Indiana University||Bloomington, IN||1982|
|B.S. Biology/Chemistry||Marquette University||Milwaukee, WI||1980|
|Ph.D. Microbiology||Indiana University||Bloomington, IN||1985|
- Post-doctoral Experience
- Postdoctoral Associate, University of Tennessee, Memphis, TN, 1985-1986
Postdoctoral Associate, Stanford University, Stanford, CA, 1986-1989
- Honors and Awards
- Honor Award, National Center for Infectious Diseases, 2001
Fulbright Scholar, 1999
Trudeau Outstanding Young Investigator Award, American Lung Association, 1996
James K. Nakano Citation, Centers for Disease Control and Prevention, 1995
Secretary's Award, U.S. Department of Health and Human Services, 1994
Director’s Award, Centers for Disease Control, 1992
- Research Interests
- Identifying mycobacterial factors associated with latent Mycobacterium tuberculosis infections. The goal of this project is to identify bacterial and host factors that contribute to the development and maintenance of latent M. tuberculosis infection. We have developed or improved upon two in vitro and one in vivo models for latent infection, and have identified several M. tuberculosis genes including two sigma factors that are expressed exclusively during survival in these systems. One gene product in particular is being examined in clinical studies in Mexico and the U.S. as a marker of latent infection.
- Representative Publications
- Fine, K.L., M. Metcalfe, E. White, R.L. Pavlicek, R.K. Karls, and F.D. Quinn. 2014. Involvement of the autophagy pathway in trafficking of Mycobacterium tuberculosis bacilli in alveolar epithelial cells. In Review.
Pavlicek, R., K. Fine, F. Quinn, J. Posey,T. Gupta, E. White, M. Metcalfe, and R. Karls. 2014. Examining the role of Mycobacterium tuberculosis Rv3351c in host lung epithelial cell pathogenesis. In Review.
Rivera-Betancourt, O.E., R. Karls, B. Grosse-Siestrup, S. Helms, F. Quinn, and R. Dluhy. 2013. Identification of Mycobacteria based on spectroscopic analyses of mycolic acid profiles. Analyst. 138:6774-6785.
Gupta, T., K. Fine, R. Karls, and F. Quinn. 2013. Infection of Acanthamoeba polyphaga by Mycobacterium shottsii and M. pseudoshottsii. Can. J. Microbiol. 59:570-576.
Fine-Coulson, K.L., R.K. Karls and F.D. Quinn. 2012. The role of lipid raft aggregation in the infection of type II pneumocytes by Mycobacterium tuberculosis. PLoS One, 7(9):e45028.