Fredrick Quinn, Ph.D.
Professor and Head
|Ph.D. Microbiology||Indiana University||Bloomington, IN||1985|
|B.S. Biology/Chemistry||Marquette University||Milwaukee, WI||1980|
|M.A. Microbiology||Indiana University||Bloomington, IN||1982|
- Post-doctoral Experience
- Postdoctoral Associate, University of Tennessee, Memphis, TN, 1985-1986
Postdoctoral Associate, Stanford University, Stanford, CA, 1986-1989
- Honors and Awards
- Honor Award, National Center for Infectious Diseases, 2001
Fulbright Scholar, 1999
Trudeau Outstanding Young Investigator Award, American Lung Association, 1996
James K. Nakano Citation, Centers for Disease Control and Prevention, 1995
Secretary's Award, U.S. Department of Health and Human Services, 1994
Director’s Award, Centers for Disease Control, 1992
- Research Interests
- Identifying mycobacterial factors associated with latent Mycobacterium tuberculosis infections. The goal of this project is to identify bacterial and host factors that contribute to the development and maintenance of latent M. tuberculosis infection. We have developed or improved upon two in vitro and one in vivo models for latent infection, and have identified several M. tuberculosis genes including two sigma factors that are expressed exclusively during survival in these systems. One gene product in particular is being examined in clinical studies in Mexico and the U.S. as a marker of latent infection.
- Representative Publications
- Singh, U.P., Singh, S., Singh, R., Karls, R.K., Quinn, F.D., Potter, M.E. and Lillard, J.W. Jr. 2007. Influence of Mycobacterium avium subsp. paratuberculosis on colitis development and specific immune responses during disease. Infect Immun. 75:3722-3728.
Birkness, K.A., Guarner, J., Sable, S.B., Tripp, R.A., Kellar, K.L., Bartlett, J. and Quinn, F.D. 2006. An in vitro model of the leukocyte interactions associated with granuloma formation in M. tuberculosis infection. Immunol. Cell Biol. 85:160-168.
Mehta, P.K., Karls, R.K., White, E.H., Ades, E.W. and Quinn, F.D. 2006. Entry and intracellular replication of Mycobacterium tuberculosis in cultured human microvascular endothelial cells. Microb. Path. 41:119-124.
Karls, R.K., Guarner, J., McMurray, D.N., Birkness, K.A. and Quinn, F.D. 2006. Examination of Mycobacterium tuberculosis sigma factor mutants using low-dose aerosol infection of guinea pigs suggests a role for SigC in pathogenesis, Microbiol. 152:1591-1600.
Posey, J.E., T.M. Shinnick and F.D. Quinn. 2006. Characterization of the twin arginine translocase (TAT) secretion system of Mycobacterium smegmatis. J. Bacteriol. 188: 1332-1340.