S. Mark Tompkins, Ph.D.
|B.S. Microbiology||University of Illinois||Urbana, IL||1990|
|Ph.D. Immunology||Emory University||Atlanta, GA||1997|
- Post-doctoral Experience
- Postdoctoral Associate, Immunology, Northwestern University Medical School, Chicago, IL, 1997-2002
Postdoctoral Associate, Virology/Immunology, CBER/FDA, Bethesda, MD, 2002-2005
- Honors and Awards
- Fellows Award for Research Excellence (FARE), National Institutes of Health Fellows Committee, the Scientific Directors, the Office of Research on Women's Health, and the NIH Office of Education, Bethesda, MD. Protection against lethal influenza virus challenge by RNA interference in vivo, 2004
John M. Bowen Award for Excellence in Animal/Biomedical Research, University of Georgia College of Veterinary Medicine, 2007
- Research Interests
- Research interests focus on understanding transmission and pathogenicity of zoonotic influenza virus infection and development of novel approaches to vaccination and the prevention and treatment of viral infections. This utilizes a variety of animal models and disease hosts including mice, ferrets, cats, and pigs. Studies include characterization of avian influenza filed isolates, mutagenesis of influenza viruses, novel recombinant vaccine and vaccine delivery development, therapeutic applications of RNA interference, and understanding the role of microRNAs in disease.
- Representative Publications
- Immunogenicity of avian H5N1 influenza virus recombinant vaccines in cats. Uhl EW, Harvey SB, Michel F, Perozo Y, Gabbard J, Tompkins SM, Hogan RJ. Viral Immunol. 2010 Apr;23(2):221-6.
Animal models for evaluation of influenza vaccines. Tripp RA, Tompkins SM. Curr Top Microbiol Immunol. 2009;333:397-412.
Replication and pathogenesis associated with H5N1, H5N2, and H5N3 low-pathogenic avian influenza virus infection in chickens and ducks. Mundt E, Gay L, Jones L, Saavedra G, Tompkins SM, Tripp RA. Arch Virol. 2009;154(8):1241-8. Epub 2009 Jul 3.
Recombinant vaccines for influenza virus. Tripp RA, Tompkins SM. Curr Opin Investig Drugs. 2008 Aug;9(8):836-45.
Tompkins, S. M., Z. Zhao, C. Y. Lo, J. A. Misplon, T. Liu, Z. Ye, R. J. Hogan, Z. Wu, K. A. Benton, T. M. Tumpey, and S. L. Epstein. 2007. Matrix Protein 2 Vaccination and Protection against Influenza Viruses, Including Subtype H5N1. Emerg.Infect.Dis. 3:426-435