Faculty: Biography

S. Mark Tompkins, Ph.D.
Associate Professor
Infectious Diseases
Address: Animal Health Research Center
University of Georgia
Athens, GA 30602
Office: Room 112B
Phone: (706) 542-4716
Email: smt@uga.edu
Biosketch
Ph.D. ImmunologyEmory UniversityAtlanta, GA1997
B.S. MicrobiologyUniversity of IllinoisUrbana, IL1990
Post-doctoral Experience
Postdoctoral Associate, Immunology, Northwestern University Medical School, Chicago, IL, 1997-2002

Postdoctoral Associate, Virology/Immunology, CBER/FDA, Bethesda, MD, 2002-2005
Honors and Awards
Fellows Award for Research Excellence (FARE), National Institutes of Health Fellows Committee, the Scientific Directors, the Office of Research on Women's Health, and the NIH Office of Education, Bethesda, MD. Protection against lethal influenza virus challenge by RNA interference in vivo, 2004

John M. Bowen Award for Excellence in Animal/Biomedical Research, University of Georgia College of Veterinary Medicine, 2007
Research Interests
Dr. Tompkins' research interests focus on understanding transmission and pathogenicity of zoonotic influenza virus infection and development of novel approaches to vaccination and the prevention and treatment of viral infections. This utilizes a variety of animal models and disease hosts including mice, ferrets, cats, and swine. Studies include understanding transmission and pathogenic potential of avian influenza virus field isolates, surveillance of non-contemporary mammalian influenza viruses, mutagenesis of influenza viruses, novel recombinant vaccine and vaccine delivery development, therapeutic applications of RNA interference, and understanding the role of microRNAs in infectious disease and neoplasia. Related to this he has contributed to genome-wide screening for host genes involved in viral (influenza, measles, RSV, polio, Hendra) replication using siRNA libraries. He has also worked on a variety of approaches for development of human antibodies for prevention and treatment of infectious diseases. More recently, his research has included pathogenesis of respiratory syncytial virus (RSV) infection, development of RSV vaccines, and outcomes of respiratory virus co-infections. Finally, recent studies explore the innate immune response to viral infection is different host species, including human, swine, mouse, feline, alligator, and bat. As a Fulbright Scholar, Dr. Tompkins focused on identification of drug targets and development of novel anti-viral drugs for Hendra virus and other emerging infectious diseases. In related work, his lab is developing hand-held sensors for detection of emerging viruses such as Hendra virus, and avian influenza virus.
Representative Publications
Tompkins, S. M., C. Y. Lo, T. M. Tumpey, S. L. Epstein. 2004. Protection against lethal influenza virus challenge by RNA interference in vivo. Proc. Natl. Acad. Sci. USA. 101: 8682-8686. PMID: 15173583

Tripp, R.A. and S.M. Tompkins. 2008. Recombinant vaccines for influenza virus. Curr. Opin. Investig. Drugs 9(8):836-45. PMID: 18666031

Driskell, E.A.*, Pickens, J.A.*, Smith, J.H., Gordy, J.T., Bradley, K.C., Steinhauer, D.A., Berghaus, R.D., Stallknecht, D.E., Howerth, E.W., and S.M. Tompkins. *Contributed equally to this work. 2012 Low pathogenic avian influenza isolates from wild birds replicate and transmit via contact in ferrets without prior adaptation. PLoS One. 2012;7(6):e38067. PMID:22675507

Mooney, A., Li, Z., Gabbard, J.D., He, B., and S.M. Tompkins. 2013 Recombinant PIV5 vaccine protects against HPAI H5N1 infection when delivered intranasally or intramuscularly. J. Virol. 87(1):363-71. PMID: 23077318

Mooney, A. and S.M. Tompkins. 2013 Experimental vaccines against potentially pandemic and highly pathogenic avian influenza viruses. Future Virology, 8(1):25-41. PMID: 23440999
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