Raj Govindarajan, Ph.D.
Pharmaceutical and Biomedical Sciences
|M.S. Biochemistry||Indian Veterinary Res. Inst.||Bareilly, India||1999|
|Ph.D. Biochemistry & Molecular Biology||Univ. of Nebraska Med. Center||Omaha, Nebraska||2005|
|DVM B.V.Sc.||Madras Veterinary College||Chennai, India||1997|
- Post-doctoral Experience
- Postdoctoral Fellow, Department of Pharmaceutics, University of Washington, Seattle, WA, 2005-2008.
- Honors and Awards
- Developmental Research Program Award, Winship Cancer Institute, Emory University, 2009-2010
Training Support Grant, Center for Funding AIDS Research, University of Washington, 2007
Podium Presentation Award, AAPS Workshop on Drug Transporter, 2007
Presidential Fellowship, University of Nebraska System, 2004-2005
Norm and Bernice Harris Award for Outstanding Work in Cancer Research during Graduate Studies, University of Nebraska Medical Center & Eppley Cancer Center, 2003
Graduate Fellowship, University of Nebraska Medical Center, 2002-2005
Best Poster Award (life sciences), Midwest Students Biomedical Research Forum, Omaha, NE, 2002
- Research Interests
- Drug transporters are proteins that allow drugs to enter cells or, in some cases, act to keep them out. Because they are expressed in multiple tissues in the body, they play important roles in governing drug disposition. By directing drugs to specific cellular and subcellular domains, drug transporters could also play a crucial role in determining drug efficacy and toxicity. Hence, understanding the spatial, temporal, and functional regulation of drug transporters could provide a better insight into the pharmacological action of drugs. The importance of such studies is exemplified through narrow therapeutic-index drugs and those used in multi-drug regimen, as the resulting toxicities often hamper courses of treatment. Understanding the role of drug transporters could provide opportunities to modulate their function or modify the time, duration, combination or sequence of drugs administration to achieve more favorable therapeutic outcomes.
- Representative Publications
- Veltkamp SA, Pluim D, van Eijndhoven MA, Bolijn MJ, Ong FH, Govindarajan R et al. (2008) New insights into the pharmacology, distribution, and cytotoxicity of gemcitabine and 2í,2í-difluorodeoxyuridine, Mol Cancer Ther., 7(8):2415-25
Govindarajan R, Endres CJ, Whittington D, LeCluyse E, Pastor-Anglada M, Tse CM and Unadkat JD (2008), Expression and hepato-biliary transport characteristics of equilibrative and concentrative nucleoside drug transporters in sandwich-cultured human hepatocytes, Am J Physiol Gastrointest Liver Physiol., 295(3):G570-80
Govindarajan R, Bakkhen AH, Hudkins KL, Lai Y, Tse CM, Casado FJ, Pastor-Anglada M and Unadkat JD (2007), In situ hybridization and immunohistochemical localization of concentrative and equilibrative nucleoside drug transporters in the human intestine, liver, kidneys and the placenta, Am J Physiol Reg Integ Comp Physiol. Vol. 293:R1809-1802
Rao PS, Govindarajan R, Mallya K and Rao US (2005) Characterization of a new antibody raised against the NH3-termius of P-glycoprotein, Clin. Can. Res., 15; 11 (16):5833-9.
Govindarajan R, et al. (2002) Impaired trafficking of connexins in Androgen-independent human prostate cancer cell lines and itís mitigation by α-Catenin. J Biol. Chem., 277, (51), 50087- 50097.