Duncan Krause, Ph.D.
Professor of Microbiology, Director, Faculty of Infectious Diseases
Faculty of Infectious Diseases
|Ph.D. Microbiology||Univ. of North Carolina||Chapel Hill, NC||1982|
|B.S. Microbiology||Auburn University||Auburn, AL||1978|
- Post-doctoral Experience
- Post-Doctoral Scientist, Department of Microbiology / Immunology, University of South Alabama College of Medicine
- Honors and Awards
- Fellow, American Association for the Advancement of Science (December 2009-present)
Research Career Development Award, National Institutes of Health, 1990-1995
University of Georgia Creative Research Medal, 1999
- Research Interests
- Our research focuses primarily on the molecular and cell biology of Mycoplasma pneumoniae, which causes bronchitis and primary atypical or "walking" pneumonia in humans. M. pneumoniae is responsible for about 20% of all pneumonias and is the leading cause of pneumonia in older children and young adults. Adherence to respiratory epithelium is mediated by a polar differentiated terminal organelle, which also constitutes the motor for gliding motility. Gliding and cytadherence are essential for mycoplasmas to evade mucociliary clearance and establish infections, and we use a normal human bronchial epithelium model to explore early events in infection of the conducting airways. A major goal of our research is to define the organization, assembly, regulation, and functional maturation of the terminal organelle in cytadherence and gliding motility and thereby identify new targets for intervention. In addition, with colleagues in the UGA Nanoscale Science and Engineering Center, we are using nanorod array-surface enhanced raman spectroscopy as a diagnostic platform for the rapid and effective detection of mycoplasmas in human and poultry infections.
- Representative Publications
- Hennigan, S.L., J.D. Driskell, N. Ferguson-Noel, R.A. Dluhy, Y. Zhao, R.A. Tripp, and D.C. Krause. 2012. Detection and differentiation of avian mycoplasmas by surface-enhanced Raman spectroscopy based on silver nanorod array. Appl. Env. Microbiol. 78:1930-1935. PMID:22210215
Szczepanek, S.M., S. Majumder, E.S. Sheppard, X. Liao, D. Rood, E.R. Tulman, S. Wyand, D.C. Krause, L.K. Silbart, and S.J. Geary. 2012. Vaccination of BALB/c mice with avirulent Mycoplasma pneumoniae P30 mutants results in disease exacerbation upon challenge with a virulent strain. Infect. Immun. 80:1007-1014. PMID:22252865
Hasselbring, B.M., E.S. Sheppard, and D.C. Krause. 2012. P65 Truncation impacts P30 dynamics during Mycoplasma pneumoniae gliding motility. J. Bacteriol. 194:3000-3007. PMID:22544269
Page, C.A. and D.C. Krause. 2013. Protein kinase/phosphatase function correlates with gliding motility in Mycoplasma pneumoniae. J. Bacteriol. 195: 1750-1757. PMID: 23396910
Prince, O.A., T.M. Krunkosky, and D.C. Krause. 2014. In vitro spatial and temporal analysis of Mycoplasma pneumoniae colonization of human airway epithelium. Infect. Immun. In press. PMID:24246560.