Duncan Krause, Ph.D.
Professor and Director
Faculty of Infectious Diseases
|B.S. Microbiology||Auburn University||Auburn, AL||1978|
|Ph.D. Microbiology||Univ. of North Carolina||Chapel Hill, NC||1982|
- Post-doctoral Experience
- Post-Doctoral Scientist, Department of Microbiology / Immunology, University of South Alabama College of Medicine
- Honors and Awards
- Fellow, American Association for the Advancement of Science (December 2009-present)
Research Career Development Award, National Institutes of Health, 1990-1995
University of Georgia Creative Research Medal, 1999
- Research Interests
- Our research focuses primarily on the molecular and cell biology of Mycoplasma pneumoniae, which causes bronchitis and primary atypical or "walking" pneumonia in humans. M. pneumoniae is responsible for about 20% of all pneumonias and is the leading cause of pneumonia in older children and young adults. Adherence to respiratory epithelium is mediated by a polar differentiated terminal organelle, which also constitutes the motor for gliding motility. Gliding and cytadherence are essential for mycoplasmas to evade mucociliary clearance and establish infections, and we use a normal human bronchial epithelium model to explore early events in infection of the conducting airways. A major goal of our research is to define the organization, assembly, regulation, and functional maturation of the terminal organelle in cytadherence and gliding motility and thereby identify new targets for intervention. In addition, with colleagues in the UGA Nanoscale Science and Engineering Center, we are using nanorod array-surface enhanced raman spectroscopy as a diagnostic platform for the rapid and effective detection of mycoplasmas in human and poultry infections.
- Representative Publications
- Cloward, J.M. and D.C. Krause. 2009. Mycoplasma pneumoniae J-domain protein required for terminal organelle function. Molec. Microbiol. 71: 1296-1307.
Bose, S.R., M.F. Balish, and D.C. Krause. 2009. Mycoplasma pneumoniae cytoskeletal protein HMW2 and the architecture of the terminal organelle. J. Bacteriol. 191:6741-6748.
Hennigan, S.L., J.D. Driskell, R.A. Dluhy, Y. Zhao, R.A. Tripp, K.B. Waites, and D.C. Krause. 2010. Detection of Mycoplasma pneumoniae in simulated and true clinical throat swab specimens by Nanorod Array-Surface-Enhanced Raman Spectroscopy. PLoS One. http://dx.plos.org/10.1371/journal.pone.0013633.
Cloward, J.M. and D.C. Krause. 2010. Functional domain analysis of the Mycoplasma pneumoniae co-chaperone TopJ. Molec. Microbiol. 77:158-169. PMID: 20487283.
Lai, J.-F., C.L. Zindl, L.B. Duffy, T.P. Atkinson, Y.W. Jung, N. Van Rooijen, K.B. Waites, D.C. Krause, and David D. Chaplin. 2010. Critical role of macrophages and their activation via MyD88-NFκB signaling in lung innate immunity to Mycoplasma pneumoniae. PLoS ONE 5(12): e14417. doi:10.1371/journal.pone.0014417.